MOFICEPT-S (Mycophenolate Sodium 360 mg Tablet) belongs to a group of medicines known as immunosuppressive agents. Mycophenolic acid is a potent immunosuppressant agent that inhibits de novo purine biosynthesis. It was derived from Penicillium stoloniferum, and has also shown antibacterial, antifungal and antiviral properties. Mycophenolic acid is used in immunosuppressive regimens as part of a triple therapy that includes a calcineurin inhibitor (ciclosporin or tacrolimus) and prednisolone. Mycophenolic acid is available as enteric-coated tablets of delayed-release, in an effort to improve upper gastrointestinal adverse events by delaying mycophenolic acid release until it reaches the small intestine. It is prescribed to transplant recipients to prevent organ rejection.
MOFICEPT-S
COMPOSITION:
Mycophenolate Sodium 360 mg Tablet
MODE OF ACTION:
Mycophenolic acid is a selective non-competitive and reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH), that blocks the conversion of inosine-5-phosphate and xanthine-5-phosphate to guanosine-5-phosphate. Mycophenolic acid has potent cytostatic effects on T- and B- and lymphocytes. Mycophenolic acid also suppresses antibody formation by B-lymphocytes and prevents the glycosylation of lymphocyte and monocyte glycoproteins involved in intercellular adhesion to endothelial cells.
INDICATIONS
Prophylaxis of organ rejection in patients receiving a kidney transplant and in pediatric patients at least 5 years of age and older who are at least 6 months post kidney transplant.
DOSAGE
The recommended dose of MOFICEPT-S 360 tablets is 720 mg administered twice daily (1440 mg total daily dose). The recommended dose of MOFICEPT-S 360 tablets in conversion (at least 6 months post-transplant) pediatric patients age 5 years and older is 400 mg/m2 body surface area (BSA) administered twice daily (up to a maximum dose of 720 mg administered twice daily)
STORAGE
Store at room temperature not exceeding 25ᵒC.
DISCLAIMER
This information is for the medical professionals & registered medical practitioners only. This product must be consumed with the valid prescription of registered medical practitioners.